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Bone Lesions Case 4 Background

Background: Osteomyelitis

Osteomyelitis is a progressive infection of the bone and bone marrow resulting in inflammatory destruction of the bone, necrosis, and new bone formation. It can occur following hematogenous or contiguous spread of infection.
  • Classic hematogenous spread is from S. aureus in pediatrics or salmonella in patients with sickle cell anemia. It most commonly affects the metaphysis of the tibia (50%), femur (30%), or fibula (12%).
  • Contiguous infections tend to be polymicrobial and most commonly occurs after trauma, with ulcers, and in patients with diabetes and vascular insufficiency.